mTORC1 is composed of mTOR, regulatory-associated protein of mTOR (Raptor), mammalian LST8/G-protein β-subunit-like protein (mLST8/GβL) and the PRAS40 and DEPTOR partners [19] and is a master regulator of protein synthesis that couples nutrient sensing to cell growth and cancer cell survival. Here, MLST8 is linked to cancer.