ITGB3 and neoplasm: In addition, silenced MDA-MB-231 cells showed fewer and smaller lung metastases in an in vivo mouse model, consistent with previous results [71] showing that downregulation of ITGB3 impairs spontaneous metastasis but not growth of the primary tumour and that ITGB3 is required by the tumour cell and not by the stroma surrounding the tumour.