Previous studies showed that the nonsynonymous SNP in PRKCH increases the risk of stroke in the Japanese and Chinese population [15, 19] and confer increased risk of RA through aberrant T cell-mediated autoimmune responses [20], and act as a higher risk genotype for severe gastric atrophy due to the dysregulation of PKCη signal transduction pathway(s) [16]. The gene discussed is PRKCH; the disease is chronic atrophic gastritis.