Notably, we found that compared to IR group, MCAO rats treated CL in IR-CL and siCon-CL groups had more proliferative vessels, higher expression of VEGF and VEGFR2 in the peri-infarction area, partially confirming that CL play its neuroprotective roles more than by activating anti-oxidative pathway. The gene discussed is KDR; the disease is infarction.