By immunohistochemistry several transcription factors implicated in EMT induction, such as SLUG (SNAI2), TWIST1 and ZEB1 are all up-regulated in ATC compared to normal thyroid and well-differentiated thyroid cancers and coordinately act to repress E-cadherin (CDH1) expression [32–34]. Here, ZEB1 is linked to thyroid gland carcinoma.