Further stratified analysis of smoker stage I patients successfully identified additional 3 miRNAs, miR-23a-3p, miR-223-3p and miR-451a as smoking responsive miRNA in early stage lung adenocarcinoma and upregulation of miR-23a-3p was strongly higher in EGFR-wt genotype while upregulation of miR-223-3p and miR-451a were significantly higher in EGFR-mut genotype. This evidence concerns the gene EGFR and lung adenocarcinoma.