Here, we conducted an explorative miRNA expression study in plasma and surgically resected tumor tissues from smoker males with lung adenocarcinoma harboring wild type and mutated EGFR gene using miRNA microarray and qRT-PCR, and found a group of miRNAs correlating with the EGFR mutational status, especially in early stage of male smoker patients. The gene discussed is EGFR; the disease is neoplasm.