The mean methylation of the 1,214 aDNAm’s was similar by tumor subtype for Luminal A (mean beta 0.29), Luminal B (mean beta 0.31), and HER2 breast cancers (mean beta 0.28), but was statistically different for Basal (mean beta 0.23) (Figure 5B, Supplementary Figure 1B). This evidence concerns the gene ERBB2 and breast cancer.