SIRT1 and cancer: While in the stress situation, SIRT1 has presented higher concentration value for sequences next to genes related to pathways involved in the establishment of cancer phenotype, like those related to migration, proliferation, angiogenesis, stress response, adhesion, invasion, carbohydrate metabolism, tumor growth, inflammation, chemotaxis, cell death, and cell survival (Figure 2A–2B, Supplementary Table 3).