AKT1 and liver dysplastic nodule: The objectives of this study were 1) to measure physiological and biochemical indexes in STZ-induced diabetic mice, 2) to examine the morphology changes by HE, PAS and Masson staining, and 3) to determine whether the better effects of CAPE-pNO2 on DN occurred via the Akt/NF-κB/iNOS pathway using in vivo and in vitro methods.