CD274 and neoplasm: A clinical trial combining GM-CSF and hypofractionated RT of 35 Gy in 10 fractions in 41 patients of several tumor types reported two CRs and six PRs.8 Moreover, conventionally fractionated RT synergized with anti-PD-L1 in different mouse models and induced the formation of antitumor immunological memory.64,65 Indeed, the effects of conventionally fractionated RT on IT efficacy may be underestimated due to the technical difficulties in applying many sequential RT doses to mice.