CD8A and neoplasm: Interestingly, a preclinical study showed that radiation doses above 12–18 Gy attenuate the immunogenicity by cytosolic DNA degradation induced by exonuclease Trex1, whereas lower doses rather stimulate IFN-β secretion, activating a subset of DCs critically important for CD8 T-cell priming, allowing tumor rejection (abscopal effect) when combined with immune-checkpoint blockade.136 LD irradiation has been shown to have immunomodulatory capacity both when applied locally or as TBI.