STING1 and neoplasm: Two studies have found that this rare basic leucine zipper ATF-like transcription factor 3 (BATF3) dependent DC subset is critical for the synergistic effects of RT and IT, including abscopal effects.26,75 In this line, it is proposed that DNA released from dying cells is able to turn on the transmembrane protein 173 (STING) pathway in tumor-surrounding DCs as a key element in the ignition of adaptive antitumor immunity.