The summary ORs of meta-analysis (OR=1.43, 95 % CI=1.15 to 1.78; P=0.002) revealed that there was a significant positive association between colorectal adenoma incidence and insulin intake between T2DM patients according to the 5 including studies (Figure 5(Fig. 5); References in Figure 5: Chung et al., 2008[7]; Dash et al., 2013[9]; Jain et al., 2016[18]; Wong et al, 2012[39]; Eddi et al., 2012[12]). The gene discussed is INS; the disease is colorectal adenoma.