Zhu et al. (2016[52]) reported that none of the AKT1 (rs2494750, rs2494752 and rs10138277) and AKT2 (rs7254617 and rs2304186) variants showed an association with esophageal squamous cell carcinoma (ESCC) risk in an Eastern Chinese population. Here, AKT2 is linked to esophageal squamous cell carcinoma.