Hyper-activation of the PI3K/AKT/mTOR pathway results in substantial dysregulation of normal cellular functions, which may lead to various human cancer development (Yuan and Cantley, 2008[49]; Knowles et al., 2009[25]; Platt et al., 2009[35]; Porta et al., 2014[36]; Houede and Pourquier, 2015[21]; Tan et al., 2015[43]; Yuge et al., 2015[50]; Guerrero-Zotano et al., 2016[18]). The gene discussed is PIK3CA; the disease is cancer.