PIK3CA and breast carcinoma: Mutations of PI3K/AKT/mTOR pathways are frequently found in cancer, particularly breast cancer where about 60 % of tumors harbor genetic alterations that hyperactive this signaling pathway and was found to be associated with cellular transformation, carcinogenesis and drug resistance (Engelman, 2009[14]; Guerrero-Zotano et al., 2016[18]).