It has been shown that miR-490-5p suppresses tumor growth in renal cell carcinoma by binding to the 3'-UTR of the PIK3CA mRNA and reduce the expression of PIK3CA at both mRNA and protein levels, which further inhibits phosphatidylinositol 3-kinase/Akt signaling pathway (Chen et al., 2016[9]). Here, AKT1 is linked to hereditary clear cell renal cell carcinoma.