The rs2677764 variant of PIK3CA showed a significant association with endometrial cancer (Lacey et al., 2011[27]), while other variants of PIK3CA (rs2699905, rs7641889, rs7641983, rs7651265, rs6443624, rs7640662, rs2677760, rs3729692, rs1607237, rs6786049) were not associated with the disease. The gene discussed is PIK3CA; the disease is endometrial cancer.