PEBP4 and early-onset autosomal dominant Alzheimer disease: Indeed, Hohman et al. 59 identified a gene-gene interaction involving PEBP4 associated with late onset Alzheimer’s disease (AD) across 13 independent datasets, and decreased expression levels have been found in hippocampus of both AD patients and mouse models for another phosphatidylethanolamine binding protein, the PEBP160–62, which has also shown alterations after methamphetamine and morphine administration63,64.