As it is appreciated that bacterial cell surface structure such as lipopolysaccharides (LPS), CP, PNAG, glycoproteins and WTAs play crucial roles in bacterial pathogenesis, antibiotic resistance, host-pathogen interaction and antibiotic resistance, clearly, further development of whole cell FTIR spectroscopy will enable efficient and specific detection and quantification of bacterial cell surface glycostructures of important diagnostic value, help developing novel specific, fast, convenient, phenotyping and diagnostics tools for detecting bacterial infections. Here, ART4 is linked to bacterial infectious disease.