CD140a+ Sca-1+ mesenchymal stromal areas of CMS5a tumours in BALB/c wild-type or nude mice disappeared on day 3 after transfer of GW4869-untreated Thy-1.1+ DUC18 CD8+ T cells (Fig. 7c) and persisted thereafter (Fig. 7c: in BALB/c wild-type), demonstrating a correlation between tumour infiltration of EV-producing CD8+ T cells and depletion of the mesenchymal stroma. This evidence concerns the gene CASP3 and neoplasm.