This report suggested that CD8+ T cells have a tumoricidal function that involves an unknown mechanism in addition to direct tumour cell killing, e.g., cytotoxicity against tumour stromal cells, modulation of tumour angiogenesis and/or vascularisation, intrusion into tumour or tumour stromal areas and prevention of tumour invasion and metastasis by acquisition of mesenchymal-like properties in part in an EV-mediated fashion. This evidence concerns the gene CD8A and neoplasm.