When DUC18 CD8 EVs and BALB CD8 EVs were injected into subcutaneous CMS5a tumours in Thy-1.1+ MSC-chimeric BALB/c mice, nearly all tumour Thy-1.1+ cells, including 5–7% of transferred CD140a+ Sca-1+ MSCs and 22% of MSC-differentiated cells, disappeared (Fig. 1e). Here, CASP3 is linked to neoplasm.