Indeed, placebo-treated 12-month-old 3×Tg-AD mice exhibited a significant reduction of GFAP expression compared to placebo-treated Non-Tg (Fig. 4a, b), and immunofluorescence revealed that um-PEA restored GFAP expression in the CA1 subregion of the hippocampus (Fig. 4e, f). The gene discussed is GFAP; the disease is Alzheimer disease.