Having demonstrated that selective TNFR1 antagonism with GSK1995057 reduced neutrophilic pulmonary inflammation, microvascular permeability and endothelial cell activation/injury in complementary in vitro and in vivo models, we undertook a double-blinded, placebo-controlled clinical trial to determine the effects of nebulised GSK1995057 in an LPS-induced model of acute lung injury in healthy human volunteers. The gene discussed is TNFRSF1A; the disease is inflammatory response.