SORT1 and cancer: Sortilin has conversely also emerged as a major cause of malignancies in a range of diseases (5), including cancer (6, –, 9), type 2 diabetes mellitus (10), hypercholesterolemia (11, –, 13), atherosclerosis (14, 15), and neurodegenerative disorders (16, 17), such as Alzheimer's disease (18, 19).