The extravasation of monocytes and subsequent macrophage differentiation into M1, M2, or TEM phenotypes is triggered by the release of macrophage chemoattractants (e.g., TAF) from the tumor hypoxic tissue, as well as by the concentration of Ang2 secreted by the neovasculature, favoring monocyte differentiation into TEM (Eq. The gene discussed is ANGPT2; the disease is neoplasm.