NLRP3 and cryopyrin-associated periodic syndrome: MWS is part of a spectrum of cryopyrin-associated periodic syndromes (CAPS) which also includes two other clinical phenotypes, the less severe ‘familial cold auto-inflammatory syndrome’ (FCAS), and the more severe ‘neonatal-onset multisystem inflammatory disease’ (NOMID) or ‘chronic infantile neurological cutaneous articular syndrome’ (CINCA) [1, 3, 4].