These genes were found to be highly expressed in breast tumors considered molecular apocrine, based on their active AR signaling (i.e., expression of genes induced by androgen in LNCaP prostate cancer cells), weak ER signaling, and morphological hallmarks of apocrine tumors such as abundant eosinophilic cytoplasm and prominent nucleoli [6]. Here, ESR1 is linked to Familial prostate cancer.