Relative expression of core amplicon genes normalized to levels in HER2-diploid tumors are similar in HER2A breast, bladder, head and neck, endometrial, cervical, ovarian, and colon cancers, and are significantly lower in HER2A gastric, lung, kidney, and uterine tumors (one-sided t test in comparison to HER2A breast, FDR p = 0.013, 0.001, 0.003, and 0.025, respectively). The gene discussed is ERBB2; the disease is malignant colon neoplasm.