Upon binding to its receptors, TACI, BAFF receptor, and B-cell maturation antigen, BLyS activates signals for B-cell survival and maturation with belimumab effect via depletion of recently formed, rather than memory, B cells or long-lived plasma cells in SLE [6–8]. The gene discussed is TNFSF13B; the disease is systemic lupus erythematosus.