FRA-1 targets influence tumor cell proliferation, invasion and metastasis including: plasminogen activator, urokinase/plasminogen activator urokinase receptor (plau/plaur) [10, 21], matrix metalloproteinase 1 (mmp-1) [22], matrix-metalloproteinase-9 (mmp-9) [12], chloride channel accessory 2 (clca2) [18], adenosine receptor A2B (ador2b) [10], AXL tyrosine kinase receptor (axl) [23] and microRNAs, such as miR-221/222 [24]. The gene discussed is MMP1; the disease is neoplasm.