PRKN and Parkinson disease: Indeed, knockdown of transcripts encoding proteins integral to mitochondrial quality control, such as the mitophagy mediator dct-1/BNIX3, Parkinson’s disease (PD) genes pink and parkin (pdr-1), and the mitochondrial unfolded protein response (mUPR) gene ubl-5, increase the number of exophers produced by proteo-stressed neurons, suggesting that poor mitochondrial quality is linked to elevated extrusion.