Furthermore, we also found that phosphorylation of IKK, IκB-α, and NF-κB as well as expression of two pro-inflammatory cytokines IL-1β and TNF-α in FCD lesion tissue were significantly higher than those in peri-FCD tissue, which suggested that NF-κB inflammatory pathway was activated in FCD lesion. This evidence concerns the gene TNF and fleck corneal dystrophy.