And the percentage of TLR4-positive astrocytes in lesion tissue was significantly higher than that in control tissue (62.5 ± 7.8% vs. 13.9 ± 8.1%; n = 8, P < 0.01; Fig. 4q), which suggested that there is also upregulation of TLR4 in astrocytes of FCD lesion. The gene discussed is TLR4; the disease is fleck corneal dystrophy.