Regarding the association with HCV, several studies have suggested that SNPs of these lipid-metabolic regulators correlate with HCV infection; e.g., an SNP in LDLR exon 13 (rs5925) is associated with susceptibility to HCV infection [12]; an SNP in LDLR exon8 (rs11669576) is associated with severity of hepatic fibrosis; and an SNP in LDLR exon10 (rs5930) is associated with viral clearance and overall inflammation of the liver [13]. The gene discussed is LDLR; the disease is Hepatic fibrosis.