LDLR and Disorder of lipid metabolism: Based on the findings mentioned above, we can speculate that a relationship exists between HCV infection and lipid metabolism disorders through SNPs of APOB-100, whereby the AA genotype (minor allele homozygote) of rs1042034 could facilitate serum LDL uptake via LDLR on hepatocytes by modifying their mutual affinity and interaction, and consequently, the serum LDL-C level could be decreased.