In partial agreement with these studies, we recently showed that miR-144, -374 and -221 are downregulated in the total blood of AD subjects and ADAM10 protein levels are significantly decreased upon transient overexpression of miR-221 in SH-SY5Y cells, but not altered after overexpression of miR-144-5p and miR-374, indicating the specificity of miR-221 in the regulation of ADAM10 levels [85]. This evidence concerns the gene ADAM10 and Alzheimer disease.