MTOR and acute myeloid leukemia: Abnormal constitutive signaling through intracellular pathways is often observed in AML, including the phosphatidylinositol-3-kinase-Akt-mechanistic/mammalian target of rapamycin (PI3K-Akt-mTOR) pathway that seems to be important both in normal and leukemic hematopoiesis [3,4,5].