On a larger scale, a recent multi-stage, genome-wide association study on over 7000 PC patients with over 14,000 control individuals identified numerous susceptibility loci for PC lying in close proximity to a variety of genes, some of which have previously been implicated in oncogenesis (e.g., BCAR1, KLF14, PDX1, CHEK2, TERT) [23]. This evidence concerns the gene CHEK2 and pachyonychia congenita.