NF-1 has a complete penetrance, but each affected individual presents with some of the widely variable disease manifestations.[8] People with NF-1 can develop cardiac and vascular disease, which is known as NF-1 vasculopathy.[3] But the frequency, natural history, and pathogenesis are uncertain because screening is not routine and many patients are asymptomatic throughout life.[9] The patient in the present case is the proband of the family and is considered to have de novo mutation because neither of her parents has manifestations of NF-1. This evidence concerns the gene NF1 and vascular disorder.