COL3A1 and Ehlers-Danlos syndrome, vascular type: Moreover, investigators of a similar case of vEDS caused by splice mutations (c.1761 + 1G>A versus our case: c.1762 – 2A>G) in the COL3A1 gene reported a rapidly progressing arterial aneurysm and early death of the patient due to a ruptured subclavian artery.[20] Thus, it is important for his family to be informed about the future risk of vascular or surgical complications due to fragile tissues, the necessity of close follow-up for the potentially fatal complications of the condition and be strongly encouraged to receive genetic counseling.