RYR2 and arrhythmogenic right ventricular cardiomyopathy: The exact pathogenesis of ARVC is still unclear, but this involves a genetic factor.[34] Currently, the known genetic mutations associated with ARVC include PG, PKP2, DSP, DSC2, DSG2, TGFβ3, TMEM43, RYR2, TTN, and JUP.[35] Most of the patients reported had a family history and genetic tendency.[36] However, the patients included in this study had no family history of ARVC or SCD, and this may be associated with the absence of comprehensive clinical data.