Epidemiological studies showed that acidosis and inflammation are strongly linked in CKD patients.[19,20] In experimental models, exposure of epithelial and macrophages to reductions in pH lead to increased inflammatory markers and development of atherosclerotic CVD.[7,21] Furthermore, MA leads to enhanced production of catecholamines, endothelin-1, and aldosterone; which can contribute to changes in left ventricular mass and geometry.[22] However, in our study we found no relationship between MAC and inflammatory markers. Here, EDN1 is linked to chronic kidney disease.