The human adiponectin gene encoding the adiponectin protein,[2] is negatively correlated with fasting glucose, insulin-resistance (IR), and T2DM.[3–6] Epigenetic modifications, such as DNA methylation, of the adiponectin gene affecting gene transcription and health status, may be involved in T2DM.[7] The methylation in the promoter region of this gene may result in repressed transcriptional activity of the adiponectin gene and low plasma adiponectin levels, leading to pathogenesis and progression of T2DM. Here, ADIPOQ is linked to type 2 diabetes mellitus.