Genome-wide association studies (GWAS) have been used to evaluate the associations between the adiponectin gene promoter polymorphism, especially the rs266729, and T2DM.[8,9] However, limitations of these studies have included: first, the reduction of the problem to a single comparison, either by performing 2 separate pairwise comparisons or by assuming a specific underlying genetic model. Here, ADIPOQ is linked to type 2 diabetes mellitus.