While PRC1.6 (also known as E2F6-PRC1 and PCGF6-PRC1) is similar if not identical to L3MBTL2 (Lethal(3)Malignant Brain Tumor-Like 2)-containing complexes [12,13] and the E2F6 repression complex [14], it is specifically associated with several proteins that are not found in other ncPRC1s (Fig 1A), [7,15]. Here, E2F6 is linked to brain cancer.