Interestingly, loss of ING3 expression led to decreased expression of MELK, UBE2C, TOP2A, CCNB2, and AURKB. These genes have been reported to be highly expressed in high-grade PC patients (Kuner et al, 2013), while CAMK2N1 forms a transcriptional network with NUSAP, UBE2C, and HMMR whose expression regulates proliferation of treatment-resistant cancer cells (Wang et al, 2014a). This evidence concerns the gene CCNB2 and pachyonychia congenita.