PCNA and cancer: The importance of the role played by ING3 in tightly controlling cellular proliferation of cancer cells is also highlighted by the loss of expression of several cyclin genes (CCNA2, CCNB1, CCNB2, and CCND1) and gain of cell cycle inhibitors (CDKN1A and CDKN1B) as well as apoptotic genes (BAX) concomitant with the silencing of ING3.