Interestingly, the expression of MELK highly correlates with cell cycle genes AURKB, CCNB2, TOP2A, and UBE2C, which are upregulated in high-grade PC (Kuner et al, 2013) and appear to form a transcriptional network whose expression requires ING3 (Figure 3A), suggesting that ING3 regulates this pathway. Here, TOP2A is linked to pachyonychia congenita.