Two mutations in HSPB1 (p.Gln190His and p.Al204Glyfs*6) were reported recently in patients with amyotrophic lateral sclerosis (ALS) phenotype, which suggested overlap of ALS and CMT2F/HMN2B (Capponi et al.,2016). Here, HSPB1 is linked to amyotrophic lateral sclerosis.