2009). Loss of GH secretion pulsatility is characteristic of the diminished GH concentrations observed with obesity (Veldhuis et al. 1995; Langendonk et al. 1999). Exercise training can increase plasma GH release (Felsing et al. 1992; Weltman et al. 1992, 2006; Kanaley et al. 1997; Pritzlaff et al. 1999; Pritzlaff‐Roy et al. 2002), the magnitude of which is intensity dependent (Pritzlaff et al. 1999; Pritzlaff‐Roy et al. 2002). Here, GH1 is linked to obesity due to melanocortin 4 receptor deficiency.