2002). Cell culture studies have observed possible functions of VDR that may influence the development of preeclampsia by maintaining an inflammatory response (Tamblyn et al. 2015), placental implantations in early pregnancy (Uitterlinden et al. 2004), and endothelial repair (Versen‐Hoynck et al. 2014). Cell culture studies have also revealed that, through a VDR‐mediated mechanism, 1,25(OH)2D3 suppresses renin transcription, which is important in the regulation of blood pressure (Li et al. 2002). Here, REN is linked to preeclampsia.