PDGFRA and neoplasm: In glioblastoma, autocrine signalling by PDGF-CC/PDGFRα has been proposed to have a role in tumour development and Lokker et al. detected concomitant expression of PDGF-CC and PDGFRα in 6/6 tested glioblastoma cell lines, and 5/5 investigated primary glioblastoma tissue samples [26].