PLP1 and Anxiety: Studies on mice with mutations in oligodendrocyte-related genes, such as Cnp1 and Plp1, and a mouse model of cuprizone-induced demyelination suggest that the loss of integrity of small-diameter myelinated axons due to oligodendrocyte dysfunction may be a common mechanism underlying reduced anxiety-like behaviors (Ganter et al., 1999; Evangelou et al., 2001; Lappe-Siefke et al., 2003; Edgar et al., 2004; 2009; 2011; Tanaka et al., 2009; Xu et al., 2009).