CD4 and familial pancreatic carcinoma: In addition to induction of IL-10 expression in Foxp3+ Treg cells, TGFβ from CD4+Foxp3+ Treg cells and pancreatic cancer also stimulates transcription factor Foxp3 expression in Foxp3− naïve T cells, leading to differentiation of Foxp3+ Treg cells [42, 43].