Furthermore, inflammation facilitates EMT, and an increase in the number of CPCs was observed in Pdx1-Cre; RosaYFP and Pdx1-Cre; KrasG12D; RosaYFP mouse pancreatitis models [6], to some degree, which could prove the significant role inflammation plays in the PDAC metastasis. This evidence concerns the gene PDX1 and pancreatitis.