In addition to immunotherapy, vaccines are being evaluated in the adjuvant setting for pancreatic cancer; 5-Fluorouracil (5-FU)-based chemoradiation combined with a pancreatic cancer vaccine of irradiated granulocyte-macrophage colony stimulating factor (GM-CSF) is undergoing clinical trials, and a vaccine was recently developed against the mesenchymal-associated transcription factor brachyury, which is currently undergoing clinical trials for the treatment of solid tumors [85]. The gene discussed is TBX1; the disease is familial pancreatic carcinoma.