In a study investigating the association of retinitis pigmentosa with NPHP, Otto et al. found a novel gene IQCB1 that associates with retinitis pigmentosa GTPase regulator (RPGR) and calmodulin in the retinal connecting cilia, an analogous structure of the ciliary transition zone (53). The gene discussed is IQCB1; the disease is retinitis pigmentosa.