CUR acts by increasing the total level of GSK-3β in NCCIT human embryonic carcinoma cells with apoptosis induction, and a plethora of studies in the last years underlined the favorable impact of CUR on PI3K/PTEN/AKT/mTORC1/GSK-3 pathway in different types of cancer [139] and pathologies such as neurological diseases [140], obesity [141], diabetes [142], and cardiovascular disease [143]. This evidence concerns the gene AKT1 and diabetes mellitus.