According to GEO database (https://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1375), we observed that 63 samples of human melanoma and benign nevi reported in the dataset GDS 1375 [36] show GSK-3α expression significantly upregulated in melanoma biopsies as compared to benign nevi human biopsies (1200 units versus 901 units, p < 0.0001), while GSK-3β expression appears unmodified (791 units versus 680 units, p < 0.2). This evidence concerns the gene GSK3B and melanoma.