The TLR4·MD-2 receptor complex senses picomolar amounts of LPS and initiates the biosynthesis of diverse mediators of inflammation (such as tumor necrosis factor-TNF-α, interleukin 6 (IL-6) and IL-8) thereby triggering a downstream pro-inflammatory signaling cascade aimed at the clearance of infection [8]. This evidence concerns the gene CXCL8 and infection.