Consistent with this finding, IL-6 and IL-8 released from myofibroblasts in tumor microenvironment upregulate S100A8/S100A9 in myeloid cells and induce the differentiation of myeloid cells into S100A8/S100A9-expressing myeloid-derived suppressor cells and M2 macrophages (63). The gene discussed is S100A9; the disease is neoplasm.