TNF and B-cell chronic lymphocytic leukemia: As shown in Figures 3 and 4 CLL cells cultured with CXCL12 induced significantly greater suppression of CD3+ T-cell function, including TNF-α, IFN-γ and IL-2 production, as well as cytotoxicity as measured by CD107a degranulation, in comparison with CD3+ T cells cultured with untreated CLL cells or with CXCL12 alone (Figure S6 in Supplementary Material).