Recent reports that lenalidomide can inhibit STAT3 phosphorylation (40, 41) and improve T-cell synapse formation and function in CLL (4, 42) led us to investigate its effect on the CXCL12/CXCR4/STAT3/IL-10/T-cells axis. The gene discussed is STAT3; the disease is B-cell chronic lymphocytic leukemia.