JUN and neoplasm: The current view is that pleiotropic functions of the HTLV-1 viral transcriptional transactivator Tax (Peloponese et al., 2007; Journo et al., 2009), such as deregulation of the signaling pathways AP-1 pathway (Fujii et al., 2000) and NF-kB (Rosin et al., 1998; Peloponese et al., 2006; Chan and Greene, 2012), and inactivation of tumor suppressors (Tabakin-Fix et al., 2006) are promitotic events, which drive CD4+ T-cell proliferation during the preleukemic stage (Matsuoka and Jeang, 2007).