In order to further elucidate the underlying mechanisms, the mRNA and protein levels of the key targets of hyperuricemia, including hepatic XOD together with renal GLUT9 (glucose transporter 9), UART1 (uric acid transporter 1), and OAT1 and gastrointestinal concentrative nucleoside transporter 2 (CNT2) were examined. This evidence concerns the gene SLC28A2 and hyperuricemia.