MAPT and Alzheimer disease: Ventricle expansion rates correlate strongly with declining cognitive performance (Carmichael et al., 2007; Nestor et al., 2008; Grimm et al., 2012; Madsen et al., 2015) and the rate of ventricle volume increase has been linked to an increase in Alzheimer’s disease (AD)-related amyloid-beta (Aβ) plaques and tau neurofibrillary tangles (Silbert et al., 2003), as well as alterations in CSF biomarker composition.